Beilstein J. Org. Chem.2018,14, 2461–2467, doi:10.3762/bjoc.14.222
carbinols afforded novel allene systems. Our study may be of help towards the total synthesis of solenopodin or klysimplexin derivatives.
Keywords: conformational analysis; low valent titanium; marine natural products; pinacol coupling; ten-memberedrings; Introduction
Eunicellane-type diterpenoids share
the plant Vellozia magdalenae [6]. Recently, prehydropyrene (6) was discovered as biosynthetic intermediate towards the diterpene hydropyrene from the Gram-positive bacterium Streptomyces clavuligerus [7]. The six- and ten-memberedrings of eunicellane diterpenoids can be either cis or trans fused